OR analysis revealed that high C4d (OR 8.0, p = 0.0001), low C3 (OR 5.03, p = 0.002) and low C4 (OR 5.1, p = 0.002) levels as well as high C4d/C4 ratios (OR 13.1, p < 0.0001) all associated significantly with LN and that high C4d/C4 ratios exhibited the highest relative odds to occur if the patient has LN (Figure 1F). This evidence concerns the gene C4A and lobular neoplasia.