To explore whether higher levels of IL-33 and sST2 found in the serum of ACD patients are linked to changes in the duodenal mucosa as a consequence of the enteropathy, indirect immunofluorescence was used to evaluate the pattern of expression of ST2 and IL-33 in duodenal mucosae sections of ACD and NC individuals. The gene discussed is IL1RL1; the disease is Abnormal intestine morphology.