Since many of the ST2+ cells were mononuclear cells infiltrating the epithelium and lamina propria, most of them were hematopoietic derived CD45+ cells (Figure 6A), as we found an increase in RDF of ST2 staining in CD45+ (Supplementary S5A), as well as, in the cellular proportion of ST2+ cells in the CD45+ population in ACD patients (Figure 6B). This evidence concerns the gene IL1RL1 and granular corneal dystrophy type II.