In contrast, the mRNA levels of IL-33 and ST2L or sST2 did not show an upregulation in ACD samples, this is probably due to a dilution effect when mRNA levels were determined in the whole tissue or difference in post-transcriptional regulation increasing IL-33 or ST2 protein expression (68–72). The gene discussed is IL1RL1; the disease is granular corneal dystrophy type II.