Another point is the role played by immunoglobulins directed to other respiratory pathogens, which could interfere with SARS-CoV-2 immunoglobulins, but both patients did not have IgM to other pathogens and were IgG positive to several respiratory pathogens, thus it does not seem that these immunoglobulins may play any role in these two COVID-19 patients. Here, CD40LG is linked to COVID-19.