Marro et al. also found that macrophages promoted autoreactive CD8+ T cell infiltration into islets in the Rip-LCMV-GP T1DM model via IFN-I signaling, and abrogation of IFN-I signaling on macrophages significantly limited the onset of T1DM (25). The gene discussed is CD8A; the disease is type 1 diabetes mellitus.