PTPN6 and colon adenocarcinoma: Given that Shp1 loss in myeloid cells drives an inflammatory, pro-phagocytic phenotype [(9), Figures 1C–G and Supplementary Figure 1F], we next tested the impact of Shp1 loss on the growth of two syngeneic tumor cell lines that develop a more immune-rich microenvironment, the breast adenocarcinoma E0771 and the colon adenocarcinoma MC38.