However, we observed reduced growth of E0771 tumors in tamoxifen-treated Ptpn6fl/flERT2-cre mice relative to control Ptpn6fl/fl mice (Figure 4E), as well as reduced tumor weight (Supplementary Figure 5C), suggesting that loss of Shp1 could drive anti-tumor immunity. This evidence concerns the gene PTPN6 and neoplasm.