To address this, we analyzed cytokine levels in MC38 tumor lysates from tamoxifen-treated Ptpn6fl/flERT2-cre and Ptpn6fl/fl mice at study endpoint and observed increased levels of the proinflammatory, myeloid-derived cytokines IL-1β, and IL-12p70 (Figure 5G). Here, IL1B is linked to neoplasm.