The value of anti-CSP antibodies has been shown by their ability to sterilely protect mice against sporozoite challenge (29), and by observations that anti-CSP IgG concentration and avidity contribute to RTS,S/AS01E-mediated protection (50) with anti-CSP antibodies estimated to prevent 32% of infections following RTS,S immunizations (51). This evidence concerns the gene DNAJC5 and infection.