Therefore, it will be interesting and significant to examine the interaction of SARS-CoV-2 nsp1 with immunophilins and the role of the Calcineurin/NFAT pathway in SARS-CoV-2 infection, for not only better understanding of nsp1 function and COVID-19 pathogenesis but also the development of antiviral therapeutics targeting the virus-host interaction (see below for further discussion). The gene discussed is SH2D3A; the disease is COVID-19.