Coincidently, SARS-CoV nsp1 has been shown to stimulate chemokine production in human lung epithelial cells (Law et al., 2007) while inhibiting antiviral IFN induction and signaling, indicating that nsp1 might be involved in the immune and inflammatory dysregulation during SARS-CoV infection. The gene discussed is SH2D3A; the disease is severe acute respiratory syndrome.