Previously, it has been reported in human fibroblasts, hepatoma cells, and lymphoblasts that highly tissue-specific genes such as MIS, are expressed as spliced transcripts in non-specific tissues, suggesting that even in the absence of tissue-specific transcriptional factors, all promoters could be minimally active when ubiquitous transcriptional factors reach their cognate DNA elements (47). This evidence concerns the gene AMH and hepatocellular carcinoma.