Disruption of FKBP52 leads to reduced expression of GR target genes in the liver and augmented hepatic steatosis as a result of diet-induced obesity (52), also observed in liver-specific GR knock out (L-GRKO) mice (26), demonstrating a functional role of the multimeric chaperone complex for hepatic GR function. The gene discussed is NR3C1; the disease is fatty liver disease.