Reduced expression of key gluconeogenic genes including Pck1, G6Pc, and Pfkfb3 in L-GRKO mice is linked to fasting hypoglycemia (26, 144–146), and around half of newborn albumin-alpha-fetoprotein-driven L-GRKO mice die within 48 h after birth, possibly due to hypoglycemia (120, 146). The gene discussed is PFKFB3; the disease is Hypoglycemia.