NR3C1 and obesity due to melanocortin 4 receptor deficiency: Disruption of FKBP52 leads to reduced expression of GR target genes in the liver and augmented hepatic steatosis as a result of diet-induced obesity (52), also observed in liver-specific GR knock out (L-GRKO) mice (26), demonstrating a functional role of the multimeric chaperone complex for hepatic GR function.