After adjustment for other risk factors, Cer(d18:1/16:0), Cer(d18:1/22:0), and Cer(d18:1/24:0) were associated with higher risk of ischemic stroke [odds ratios for one IQR increase: 2.15 (1.42–2.99); 2.90 (2.13–4.01), and 1.29 (1.10–1.69), respectively] (16). This evidence concerns the gene CBLN1 and ischemic stroke.