Furthermore, Liakos et al. observed that TGFβ1 significantly inhibits forskolin-induced steroid 11β-hydroxylase activity and CYP11B1 mRNA levels, as well as angiotensin II-induced aldosterone synthase activity and CYP11B2 mRNA levels in the human adrenocortical tumor cell line NCI-H295R (45). This evidence concerns the gene AGT and adrenal cortex neoplasm.