c-Myc is a protooncogene frequently deregulated in many human cancers, whose inhibition induces apoptosis and sensitizes MPM cells to drug-induced cytotoxicity (52); moreover, we recently showed that c-Myc is implicated in the antitumor effects of growth-hormone releasing hormone (GHRH) antagonists in MPM cell lines (22). Here, MYC is linked to cancer.