In order to clarify the potential role of TERT in lithium’s mechanism of action in BD, future studies should aim to (1) investigate the effect of lithium treatment on TERT gene expression (2) investigate the relative concentrations of TERT protein in the nucleus and mitochondria in response to oxidative stress, (3) investigate the different pathways that may mediate lithium’s effect on TERT expression and the effect of TERT on mitochondrial bioenergetics and oxidative stress, and (4) delineate the cellular effects of combining treatment with lithium and rapamycin. This evidence concerns the gene TERT and Behcet disease.