LPN/RTN causes the dose-dependent block of both human ether-a-go-go-related gene (HERG) potassium channels and delayed rectifier potassium current (IKr) channels predisposing to QT prolongation and torsade de pointes (TdP) (Anson et al., 2005; Russo et al., 2020b). The gene discussed is KCNA3; the disease is torsades de pointes.