Although a direct correlation between TRPC5/TRPC6 and Rac1/RhoA has not yet been established in cancer models, it is possible to speculate that a similar interplay may also occur in the regulation of cancer cells migration, taking into account the evidence for direct involvement of TRPC5 and TRPC6 in the increased migratory potential of several cell types (Greka et al., 2003; Xu et al., 2006; Rampino et al., 2007), including some tumors such as colon cancer and glioblastoma (Chigurupati et al., 2010; Chen L. et al. 2017; Chen Z. et al., 2017). Here, RHOA is linked to malignant colon neoplasm.