Indeed, TRPM2, TRPM7, TRPM8, TRPV2, and TRPC1 have shown to cause upregulation of MMP9 in a Ca2+-dependent manner in gastric, bladder, oral squamous, prostate and thyroid cancer cells respectively (Monet et al., 2010; Okamoto et al., 2012; Asghar et al., 2015; Cao et al., 2016; Chen L. et al. 2017; Chen Z. et al., 2017; Almasi et al., 2019). Here, TRPM2 is linked to thyroid cancer.