In an animal study, transgenic mice overexpressing Ng in the PFC show the enhanced local plasticity and increased rate of extinction learning among different behavioral tasks, suggesting that Ng signaling in the PFC may be a specific therapeutic target for the treatment of disorders that are characterized by impaired extinction of fearful stimuli, e.g., post-traumatic stress disorder, or of reward-associated stimuli, e.g., drug addiction (Zhong et al., 2015). The gene discussed is NRGN; the disease is post-traumatic stress disorder.