In addition to α-syn and Tau, TDP-43 is also a client of the MAPS pathway (Fontaine et al., 2016), but whether this HSC70/DNAJC5-dependent release of TDP-43 contributes to the spreading of TDP-43 pathology in ALS and FTD patients remains to be shown. The gene discussed is MAPT; the disease is frontotemporal dementia.