The aforementioned trimeric human Hsp70 disaggregation machinery (HSC70, DNAJB1, HSPA4) readily disassembles a variety of amyloid Tau aggregates ranging from in vitro assembled fibrils to aggregates extracted from a cell culture model to brain material of AD patients (Nachman et al., 2020). The gene discussed is HSPA4; the disease is Alzheimer disease.