Although it has been reported that GLT-1 knockdown might increase GLAST expression, another glutamate transporter (Pardo et al., 2006), whether other glutamate transporters and their cell type-specific expression, and glutamate receptors, including ionotropic and metabotropic glutamate receptors, are impacted after GLT-1 knockdown, and whether these influences participate in the cognitive improvements after Cef treatment in APP/PS1 AD mouse remain to be clarified. This evidence concerns the gene APP and Alzheimer disease.