TNFRSF1A and Cognitive impairment: For instance, one study found that levels of soluble tumor necrosis factor receptor 1(TNFR1) and TNFR2 in CSF were positively associated with the BACE1 activity and tau levels in CSF among non-demented subjects, and that levels of soluble TNFR1 and TNFR2 in CSF were associated with the conversion from mild cognitive impairment (MCI) to AD dementia (Buchhave et al., 2010).