IL17A and Alzheimer disease: In another animal models of AD including hAPP mice, 3xTg-AD mice, Mo/Hu APPswe PS1dE9 mice and Aβ1–42-Induced AD rat model, the level of IL-17A shows a significant upregulation compared with wild type mice (Jin et al., 2008; Zhang et al., 2013; Zhang Y. et al., 2015; Chen et al., 2015, 2019; Yang et al., 2015; St-Amour et al., 2019).