Similarly, high levels of Aβ protein of brain and related behavioral alterations were associated with the gut dysbiosis in APP/PS1 mice [a genetic model of AD; APP/PS1 mice are double Tg mice expressing a chimeric mouse/human APP (Mo/HuAPP695swe) and a mutant human presenilin 1 (PS1-dE9); Shen et al., 2017]. The gene discussed is PSEN1; the disease is Alzheimer disease.