Many previous studies have reported that CCH induces cognitive decline by trigging a variety of hippocampal pathologies, including β-amyloid deposition (Ai et al., 2013; ElAli et al., 2013), tau phosphorylation (Sun et al., 2015; Liu et al., 2016; Raz et al., 2019), neuronal death (Chen et al., 2017), and even impairment of hippocampal pre-synaptic plasticity (Yan et al., 2020). Here, MAPT is linked to columnar cell hyperplasia of the breast.