CASP3 and epilepsy: Excessive excitation of the N-methyl-D-aspartate receptor, which results from extracellular glutamate accumulation, causes acute nerve injury or even death, by activating calpain and the caspase-3 pathway in patients with epilepsy and in animal models of epilepsy (Baudry and Bi, 2016; Hoque et al., 2016; Ceccanti et al., 2018).