TGFB1 and CAPN5-related vitreoretinopathy: Excessive TGFβ signaling causes epithelial to mesenchymal transition (EMT) in RPE and proliferative vitreoretinopathy (PVR) and fibrosis, while Cre-mediated deletion of TGFβ in the whole eye and in vascular endothelium (but not RPE) caused choroidal neovascularization (CNV) (Schlecht et al., 2017).