MAPT and Alzheimer disease: The selenate treatment started at 9 months, an age at which THY-Tau22 mice progressively develop AD-like hippocampal Tau pathology associated with severe deficits in memory underlined by synaptic impairments (Schindowski et al., 2006; Van der Jeugd et al., 2011, 2013; Burnouf et al., 2013).