GAPDH and tauopathy: Since several reports have documented a downregulation of PP2Ac in murine models of tauopathies (Kins et al., 2001; Liu et al., 2005; Sontag and Sontag, 2014), we evaluated total levels of PP2Ac (normalized to GAPDH) in vehicle-treated and selenate-treated Tg mice by Western blotting (Figure 6C) and found them not being statistically different (Tg vehicle-treated: 1.08 ± 0.05, n = 3, Tg selenate-treated: 0.92 ± 0.08, n = 3, p = 0.174, t-tests; Figure 6D).