We selected AT8 as the antibody of choice (Su et al., 1994; Augustinack et al., 2002; Deters et al., 2009) for the histological examination because several studies suggest that PP2Ac dephosphorylates primarily the AT8 epitopes S202/T205 while other phosphorylation sites that become hyperphosphorylated during AD, detected by antibodies such as AT100, AT180, 12E8, and PHF1, are not affected (Kins et al., 2001). The gene discussed is PPP2CA; the disease is Alzheimer disease.