However, other reports on critical patients have described that numerous metabolic processes might combine to induce a hypermetabolic state characterized by a marked negative nitrogen balance; moreover, the rate of lean tissue loss is 2–3 times higher than that during starvation and lipolysis decreases as glucose intolerance develops, consequentially raising insulin levels (Burke et al., 1979; Dabrowski and Rombeau, 2000). This evidence concerns the gene INS and Glucose intolerance.