BDNF and injury: Researchers have identified miR-1-targeting BDNF in the regulation of SC proliferation and migration after nerve injury (Yi et al., 2016); in addition, miR-1 regulated chronic neuropathic pain in rats through targeting cx43 and BDNF (Neumann et al., 2015), and miR-206 can target BDNF to the regulation of the MERK-ERK signaling pathway to affect neuro stress pain (Sun et al., 2017).