Regarding hepatoprotective function of atorvastatin in this investigation, we found the following: reduced lipid peroxidation and normal biochemical liver function; these two effects may be consistent to indicate the role of atorvastatin in management of NAFLD, but simultaneously, we reported marked suppression of SOD and GPx activities in the liver in addition to the nonprotective histological effect; collectively, these results make the effects of atorvastatin in NAFLD inconsistent and nonconclusive and necessitate future research studies to further explain and resolve this issue. The gene discussed is SOD1; the disease is metabolic dysfunction-associated steatotic liver disease.