In cluster A, LCK, ZAP70, CD2, CD247, CD27, CD28, CD3E, CD3G, CD4, CD8A, CD8B, ITK, LCK, TRAT1, TBX21, FYN, and IL-7R, which are related to T-cell biology, were represented, suggesting an important role for T-cell immunity during sepsis. The gene discussed is CD28; the disease is Sepsis.