Accordingly, the bifunctional IFN-γ+IL4+TCD4+ cells in SCD (1.72% (range 0.58-3.92)) and SCD/ON (1.57% (range 0.64-2.69)) were significantly higher compared to the control group (0.14% (range 0.00-0.48)) (p = 0.0264; p = 0.0006, respectively). The gene discussed is IFNG; the disease is Schnyder corneal dystrophy.