In comparison to the healthy controls (0.02% (range 0.00-0.09)), significantly higher frequencies of bifunctional IL17+IL4+TCD4+ cells were noted in the SCD and SCD/ON groups (0.32% (range 0.10-0.47); 0.13% (range 0.00-0.35) (p = 0.0094 and p = 0.0162), respectively) (Figure 3(g)). The gene discussed is IL4; the disease is Schnyder corneal dystrophy.