When stimulated with PMA/ionomycin, the frequency of monofunctional IFN-γ+TCD4+ cells (Figure 4(a)) and IL-17+TCD4+ cells (Figure 4(c)) was increased in SCD BM compared to non-SCD BM (13.31% (range 0.55-33.68) vs. 5.45% (range 2.97-7.36) (p = 0.027, p < 0.0001), respectively). This evidence concerns the gene IFNG and Schnyder corneal dystrophy.