DKK1 and carcinoma of esophagus: In oesophageal cancer patients, transcriptomic profiling of metastasis-free regional LNs from patients with existing metastatic nodes revealed that Dickkopf-1 (DKK1), a Wnt antagonist, was the most significantly downregulated gene as compared with regional LNs from oesophageal cancer patients without metastatic nodes [32].