The profile of temporal changes of these molecules with age in SHR showed that Nox1 and Nox4 are increased already in the developing stages of hypertension (3rd month), while Nox2 upregulation was observed only in sustained hypertension (beyond 6th month of age), that might suggest a less pronounced role in the initiation of the pathology. The gene discussed is NOX1; the disease is Hypertension.