CD8A and cardiovascular disorder: Although few studies investigated the association between CD4/CD8 ratio restoration ≥0.8 and mortality, Demontès M, et al. [36] reported multimorbidity was associated with CD4/CD8 ratio < 0.8, and Marianna M, et al. [37] found CD4/CD8 ratio < 0.8 could be used as a predictor for cardiovascular diseases.