Fortunately, the results of bioinformatics analysis, Western blot analysis and luciferase activity assay revealed that miR‐761 and miR‐192‐3p could specifically target FRAS1 3’‐UTR on 2271‐‐2277 and 1879‐‐1885 sites, respectively, which confirmed FRAS1 as a common target gene of the circ102049‐miR‐761/miR‐192‐3p regulatory axis in CRC. This evidence concerns the gene FRAS1 and colorectal carcinoma.