The increased preference for sweet high caloric food in Dusp8 minor allele adds to earlier work on the association of SNP rs2334499 minor allele with the overall type 2 diabetes risk (Kong et al., 2009; Morris et al., 2012) or the increased hypothalamic insulin resistance (Schriever et al., 2020). Here, DUSP8 is linked to type 2 diabetes mellitus.