Taken together, human carriers of the minor allele of the DUSP8 SNP rs2334499, which has previously been linked to T2D risk (Kong et al., 2009; Morris et al., 2012), hypothalamic insulin resistance (Schriever et al., 2020) and to a smaller hippocampal subiculum and CA4 layer volume (Baumann et al., 2019), show a preference for sweet high caloric food compared to major allele carriers. This evidence concerns the gene DUSP8 and type 2 diabetes mellitus.