USP7 and hepatocellular carcinoma: For example, circ-deubiquitination (circ-DB) in adipose-secreted exosomes was found to regulate deubiquitination via the suppression of miR-34a and the activation of deubiquitination-related USP7 in plasma samples of hepatocellular carcinoma (HCC) patients, which could reduce DNA damage and promote HCC cell growth (Zhang et al., 2018b).