In the present study, we compared the plasma levels of GDF15, FGF21, and HN in T2D and AD patients as compared to healthy subjects, including centenarians’ offspring (OFF) who are reported to be in a better health status as compared to age-matched peers [35, 36], and we observed a differential expression pattern of these mitokines at circulating level. This evidence concerns the gene FGF21 and type 2 diabetes mellitus.