However, two recent studies showed that genetic associations with CAD risk are proportional to the change in apolipoprotein B (ApoB), the primary protein component of VLDL, LDL and intermediate-density lipoprotein (IDL) particles, and that LDL-cholesterol and triglycerides do not appear to be independent risk factors for CAD after accounting for ApoB.8 The gene discussed is APOB; the disease is coronary artery disorder.