CUL7 and cancer: Consistent with the finding that CUL7 participates in the promotion of migration and invasion in choriocarcinoma cells55, Fbxw8 expression levels are increased in human trophoblast cell lines, including choriocarcinoma90, and regulate cell proliferation23,89–91 (Fig. 2), while the effect of Fbxw8 on the tumor migration, invasion, and metastasis remains unclear, indicating that more research about the impact of Fbxw8 on cancer progression is needed.