RBX1 and neoplasm: It has also been shown that Rbx1 is related to invasion and metastasis in gastric and lung cancer tumor tissues, and the downregulation of Rbx1 expression suppresses the cell proliferation, migration, and metastasis in the two cancer cell lines and bladder and melanoma tumor cells75–80, which may be a therapeutic strategy in cancer treatment and a potential marker for evaluating the treatment outcome (Fig. 2).