To our knowledge, CUL7 has been studied in several types of tumors, and the studies suggest that CUL7 promotes the cell growth, invasion, and metastasis in most of these tumors, might play an oncogenic role in cancer and has the potential to be used as a biomarker for the prognosis of metastatic cancers (Fig. 2). This evidence concerns the gene CUL7 and metastatic malignant neoplasm.