ATG5 and colorectal carcinoma: In addition, downregulation of ATG5 or ATG7 inhibited the m-THPC-PDT-induced autophagy in CRC cells, as indicated by the m-THPC-PDT-induced increase in MAP1LC3B-II expression and a decrease in SQSTM1/p62 expression that could be counteracted by ATG5 or ATG7 downregulation (Fig. 5B, C, E, F).