As shown in Fig. 7G, H, m-THPC-PDT or VP-PDT treatment resulted in decreased phosphorylation of p70S6K and mTOR, elevated autophagic MAP1LC3B-II/MAP1LC3B-I ratio, and decreased levels of SQSTM1/p62 in CRC cells. The gene discussed is SQSTM1; the disease is colorectal carcinoma.