Owing to functional and structural similarity of MATR3 to other ALS-associated RNA-binding proteins with known RNA-recognition motifs, including TDP43, FUS and EWSR1, we asked if the eye degeneration of G4C2-30R could be suppressed by ectopic expression of TDP43, FUS and EWSR1. Here, EWSR1 is linked to amyotrophic lateral sclerosis.