The NGS dementia panel of case I.3 revealed a heterozygous nonsense mutation/stop codon c.501G>T: p.Tyr167* in ADAM10 (genomic mutation coordinates according to GRch38.p13: chr15:58665181; protein nomenclature NP_001101.1; p.Y167*), which was confirmed by Sanger sequencing (chromatogram in Fig. 1). Here, ADAM10 is linked to dementia.