The chemokine CXCL12, also known as stromal cell-derived factor-1(SDF-1), has been identified as playing a crucial role in cell migration, angiogenesis, tumor cells proliferation and metastasis, as well as in autoimmune diseases such as rheumatoid arthritis (RA) [6, 7]. This evidence concerns the gene CXCL12 and rheumatoid arthritis.