Our study found that cystatin C was linked with hs-CRP, thereby suggesting that cystatin C was involved in the pathway of the potential pathogenesis of CVD; this result can be supported by previous findings, which indicated that cystatin C is a relevant marker of the risk of CVD among relatively healthy middle-aged adults [35], predicts incident type 2 diabetes [36] and progression from normal fasting plasma glucose to prediabetes [37], and predicts the cardiovascular risk in elderly persons [38, 39] and adults of the general population [40]. This evidence concerns the gene CST3 and prediabetes syndrome.