The sensitivities of AFP ≥ 400 ng/ml, tumor diameter ≥ 5 cm, preoperative CTC ≥ 5 and multiparameter combination were 44.8, 50.0, 91.4, and 91.4%, respectively, and the specificities were 82.3, 70.9, 79.7, and 79.7% (Table 3). Here, AFP is linked to neoplasm.