Interestingly, TAMs can acquire different functional phenotypes depending on TME signals; they are capable of having either the classical anti-tumor M1 type in response to IFN-γ or lipopolysaccharide[21] or the alternative pro-tumor M2 type by IL-4, IL-10, IL-13, TGF-β and lactic acid[20]. Here, IL4 is linked to neoplasm.