For example, in the 1958 British birth cohort physical abuse and parental offending were particularly strongly associated with higher levels of CRP, fibrinogen and von Willebrand Factor (vWF) in mid-life, however no associations were observed for parental substance misuse, parental mental illness, sexual abuse, and parental death (R. E. Lacey et al., 2020b). The gene discussed is VWF; the disease is psychiatric disorder.