For TGF-β-resistant tumors, a concomitant αvβ8 upregulation must therefore be expected to promote invasion and metastasis, particularly because TGF-β also stimulates angiogenesis, epithelial-mesenchymal transition (EMT), cell motility, tumor cell stemness, and colonization of the metastatic niche [14]. This evidence concerns the gene TGFB1 and neoplasm.