Such pathogenic mechanisms have, for example, been detailed for glioblastoma (GBM) [15] and prostate cancer [16] cell lines, and for astrocytes which may control the angiogenic activity of adjacent endothelial cells by αvβ8-integrin expression-mediated regulation of local TGF-β levels [17]. This evidence concerns the gene TGFB1 and glioblastoma.