Combined with the expression profile in AML patients (GSE79605), several differentially expressed genes after HMGB1 deletion were selected, and finally, we focused on TGFBI which is a transforming growth factor beta (TGF-β)–induced protein and presents significantly high expression after HMGB1 deletion (Fig. 4a). This evidence concerns the gene TGFB1 and acute myeloid leukemia.