Interestingly, in addition to providing a correlation between ALS diagnosis and the activation of ATF6 processing in blood cells, a progressive rate of activation of ATF6 was observed only in ALS patients of younger age, versus a stable activation observed in older patients, suggesting a reduction in the buffering capacity of the UPR (Prell et al., 2019). Here, ATF6 is linked to amyotrophic lateral sclerosis.